By means of now, maximum of that typical weight reduction recommendation—reduce your energy; transfer extra, devour much less; the entirety carefully; devour many small foods each two hours all over the day, and many others.—is useless and does now not result in long-term weight reduction luck. In reality, it’s neatly established that such recommendation does now not paintings and reasons well being to become worse, to not point out it makes you depressing, combating in opposition to the incessant starvation it creates. Pointless recommendation from healthcare suppliers subsequently opened the door to pharmaceutical brokers and bariatric procedures for weight reduction, incentivizing healthcare suppliers to the waft of revenues into their wallet.

The brand new elegance of GLP-1 agonist medicine, comparable to Ozempic, Wegovy, Rybelsus, and Mounjaro, are skyrocketing in reputation because of their weight reduction results. Individuals are scrambling to procure those medicine, expected to be a $19 billion/12 months alternative for the pharmaceutical trade in brief order. In spite of their reputation, I query whether or not those medicine must had been permitted via the FDA within the first position, given their long-term possible for harmful well being results. So let’s imagine this wildly common elegance of gear and the results they wreak on well being.

At first supposed to cut back blood glucose in kind 2 diabetics, it was once famous that really extensive weight reduction additionally happens. In a single contemporary medical trial, for instance, as soon as weekly injections (handiest Rybelsus is oral; all others are injectable) ended in 52 kilos misplaced over a 12 months and a part. This ignited wild and unheard of call for for those medicine, such a lot in order that many weight reduction systems like Weight Watchers, Noom, and Calibrate embraced the medicine, including them to their systems (making you marvel, if most of these systems need to depend on a drug, what’s the aim of this system when you’ll be able to simply pass for your number one care physician and get a prescription?). 3 medicine on this elegance, Wegovy, Saxenda, and Mounjaro, had been FDA-approved for a weight reduction indication, whilst the others are used off-label, which means that healthcare insurers will want to come to a decision whether or not they are going to quilt the prices of the medicine permitted for weight reduction, spreading out the prices to you and me as payers of healthcare insurance coverage premiums.

Let’s set aside the side-effects (nausea, vomiting, diarrhea, pancreatitis) and absurd prices (generally $1000 to $1500 per 30 days). Let’s imagine the long-term penalties of taking those medicine.

Say you spent round $15,000 over 365 days via injecting the sort of medicine and misplaced 30 kilos. Of that 30 kilos, about 50% of misplaced fats is subcutaneous (buttocks, thighs, palms, chest, and many others.), 50% is belly visceral fats, the fats chargeable for lots of the issues related to extra weight (insulin resistance, kind 2 diabetes, cardiovascular possibility, fatty liver, higher possibility for Alzheimer’s dementia, breast most cancers, stroke, and many others.). In different phrases, the medicine don’t seem to be selective for probably the most problematic type of fats, belly visceral fats. Metabolic advantages on blood glucose, blood power, and many others. are subsequently restricted. Recall that belly visceral fats, now not subcutaneous fats, is chargeable for producing insulin resistance that reasons weight achieve, blocks weight reduction from fats retail outlets. Preferentially shedding belly visceral fats that results in diminished insulin resistance would subsequently boost up weight reduction; the GLP-1 agonists don’t seem to be selective for belly visceral fats.

Every other problematic factor: Of the 30 kilos misplaced, roughly 10 kilos is muscle—that’s numerous muscle. Consider 10 kilos of red meat and shedding that quantity out of your palms, chest, again, thighs, face. Now not handiest are you weaker, much less assured in navigating stairs, climbing, sporting out garden paintings, and many others., you might be additionally extra vulnerable to falls, fractures, and frailty through the years. Muscle tissues is the main determinant of basal metabolic price (BMR), i.e., the speed at which your physique “burns” energy to maintain the paintings of respiring, gastrointestinal digestion, upkeep of physique temperature, and many others., physique actions which might be ongoing and underneath mindful path. Lack of muscle subsequently generally results in 15-27% aid in BMR, an impact that persists for plenty of years after muscle loss. This can be a survival mechanism: a discount in calorie consumption is perceived via your physique as a loss of assets, hunger, and metabolic price is diminished to make sure your survival. However it additionally promises weight regain—even supposing you handle a low-calorie way of life. Shedding muscle groups with weight reduction is subsequently a pivotal and crippling construction of any manner of lowering energy, whether or not it’s a GLP-1 agonist, a bariatric process, or calorie restriction. You will regain the load.

Worse: Whilst you regain the load, it’s most commonly fats. Of the ten kilos of muscle you misplaced, you’ll regain, at absolute best, 5 kilos of muscle along side round 25 kilos of fats. You might be subsequently in worse form metabolically after the drug than you have been ahead of taking it. Your possibility for prerequisites comparable to coronary center illness and center assault, kind 2 diabetes, cognitive impairment and dementia, breast most cancers, high blood pressure and others is higher. Had the FDA required long-term follow-up proof for the results of those medicine, they might have most probably known that those medicine build up mortality, i.e., they build up possible for a lot of illnesses and shorten your lifestyles.

With GLP-1 agonists, you subsequently have a call: Forestall the drug after spending 1000’s of bucks and regain the load or keep at the drug perpetually, paying the pharmaceutical trade masses of 1000’s of bucks through the years to handle your extra slim weight. Consider a most cancers chemotherapy drug that doesn’t treatment the most cancers, however assists in keeping it from rising and metastasizing. Forestall the drug and the most cancers grows and spreads, in the end killing you. Keep at the drug at the price of many 1000’s of bucks and it assists in keeping the most cancers managed. You might be, in impact, held hostage via the drug and the pharmaceutical corporate. That is how it’s with the GLP-1 agonists.

And wait till all the ones Hollywood varieties who inject GLP-1 medicine to shed weight acknowledge what occurs for your look whilst you lose subcutaneous fats and muscle from the face and in other places: You glance 10-Two decades older.

But how you can in particular goal lack of belly visceral fats are to be had. Techniques to extend lean muscle groups with out workout are to be had. Briefly, you’ll be able to succeed in slenderness, repair younger muscularity, revel in commonplace wholesome physique composition. However it gained’t contain medicine, procedures, or the erroneous recommendation of your physician. Return in the course of the many discussions I’ve posted on this weblog and in other places and you’ll be able to save your $15,000 and keep away from antagonistic well being results whilst taking part in younger slenderness. The information I initially articulated in my Wheat Abdominal books are a get started. However, since then, the methods we use to regain younger physique composition—spice up oxytocin with recovery of L. reuteri, thrust back SIBO via restoring microbes that colonize the small gut and convey bacteriocins, upload the body-shape enhancing results of collagen peptides and hyaluronic acid absent from trendy existence, and others, all herbal however missing in most of the people’s lives—are to be had, efficient, secure, and repair more than one sides of well being and youthfulness.

Similar