The Economist ultimate week had in hopeful article on tactics to damage the cycle of HIV transmission, in particular amongst younger lady who’ve intercourse with older males. A lot of the dialogue is on PrEP

A extra promising concept is to forestall ladies and younger ladies from changing into inflamed, preferably the use of strategies which don’t require them to influence a person to put on a condom (which is hard). Amongst those are 3 PrEP strategies that experience develop into to be had lately: a vaginal ring, a day by day tablet and an injection each 2d month. Convincing ladies prone to hiv
 to make use of them can, then again, be a problem.
The vaginal ring, an insertable silicone software that releases an ARV drug and will have to get replaced each month, can cut back the danger of HIV an infection by means of up to 50%. However “it’s now not going to be everyone’s cup of tea,” admits Dr Bekker.
The day by day PREP  tablet, which comprises a mixture of ARV tablets, has been to be had in Africa for a number of years. However it has been tough to pinpoint how efficient this is because even in scientific trials too few ladies used it persistently. Some research estimate that, if used correctly, those tablets can cut back the danger of HIV an infection by means of up to 90%. However it’s exhausting to take the medicine discreetly at paintings or college and tough to cover from a mum or dad or a boyfriend.
Ladies fear about stigma…
Essentially the most promising choice is an injectable type of PrEP. This comprises a long-acting type of cabotegravir, which stops crucial level within the replication of HIV in host cells. It’s delivered as an injection, to begin with as soon as a month after which each two months, and was once integrated within the International Well being Organisation tips on HIV prevention ultimate 12 months. In scientific trials with ladies in Africa, it was once just about 90% more practical than oral PrEP.

The find out about additionally discusses the potential for different injectable PrEP therapies that are administered much less steadily (each 6 months) to support adherence. The overall article is right here.